The only thing with 22ct is that, if your piece has a LOT of confetti (like mine does), it does get TIGHT in those confetti-filled areas. IF 20ct was as readily available, I would recommend using it for highly complex designs, but I don't have a handy source even online for 20ct (I think it's not as popular as it used to be). But for areas that aren't that busy, or simpler designs, I like working on 22ct, when I work on a non-evenweave. I will likely use it for the other SQ I have in the stash,Monet's Water Lilies http://www.scarletquince.com/pat.php?pat=MON004 - it's not as complex as the L&U.
I suggest trying a small piece on it first, just to see how it works for you (in case seeing it is an issue?). I don't think you'll have any trouble at all